The Abl1 tyrosine kinase is a key player in doxorubicin-induced cardiomyopathy and its p53/p73 cell death mediated signaling differs in atrial and ventricular cardiomyocytes
The tyrosine kinase Abl1 is of critical importance in doxorubicin induced cardiomyopathy, and we propose its inhibition as means to diminish risk of cardiotoxicity.
Authors
- Alberto Inga (ORCID: https://orcid.org/0000-0002-8767-1637)
- Reinhard Spanel
- Yari Ciribilli (ORCID: https://orcid.org/0000-0001-9231-379X)
- Alessandra Bisio (ORCID: https://orcid.org/0000-0002-3326-1923)
- Jürgen Borlak
- Saravanakumar Selvaraj
- Jung‐Hwa Oh (ORCID: https://orcid.org/0000-0003-4729-9153)
Institutions
- University of Trento (IT)
- Medizinische Hochschule Hannover (DE)
- Korea Institute of Toxicology (KR)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1186/s12967-024-05623-8
- Citations
- 6
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 2.41
Funders
- Volkswagen Foundation