Single or Double Induction With 7 + 3 Containing Standard or High-Dose Daunorubicin for Newly Diagnosed AML: The Randomized DaunoDouble Trial by the Study Alliance Leukemia
The use of 90 mg/m<sup>2</sup> daunorubicin once daily in the context of classical 7 + 3 induction does not significantly improve early response and does not lead to higher remission rates or longer survival than 60 mg/m<sup>2</sup> once daily. In patients with a good early response after first induction, a second induction has only a limited impact on RFS and does not result in an OS benefit.
Authors
- Johannes Schetelig (ORCID: https://orcid.org/0000-0002-2780-2981)
- Christian Thiede (ORCID: https://orcid.org/0000-0003-1241-2048)
- Michael Krämer (ORCID: https://orcid.org/0000-0002-0251-2726)
- Markus Schaich
- Sabine Käyser (ORCID: https://orcid.org/0000-0003-3796-8843)
- Sebastian Scholl (ORCID: https://orcid.org/0000-0003-2893-3630)
- Wolfgang E. Berdel (ORCID: https://orcid.org/0000-0002-3030-6567)
- Björn Steffen
- Christoph Röllig (ORCID: https://orcid.org/0000-0002-3791-0548)
- Martin Bornhäuser (ORCID: https://orcid.org/0000-0002-5916-3029)
- Carsten Müller‐Tidow (ORCID: https://orcid.org/0000-0002-7166-5232)
- Claudia Dorothea Baldus (ORCID: https://orcid.org/0000-0002-0748-834X)
- Andreas Hochhaus (ORCID: https://orcid.org/0000-0003-0626-0834)
- Jan Moritz Middeke (ORCID: https://orcid.org/0000-0003-3250-293X)
- Dirk Niemann (ORCID: https://orcid.org/0000-0003-2356-0214)
- Jan Novák (ORCID: https://orcid.org/0000-0001-5173-3608)
- Annett Haake
- Andreas Neubauer (ORCID: https://orcid.org/0000-0002-7606-8760)
- Friedrich Stölzel (ORCID: https://orcid.org/0000-0003-0653-5332)
- Edgar Jost (ORCID: https://orcid.org/0000-0003-2998-2450)
- Regina Herbst
- Christoph Schmid (ORCID: https://orcid.org/0000-0001-7070-487X)
- Jiřı́ Mayer (ORCID: https://orcid.org/0000-0003-0567-9887)
- Barbora Weinbergerová (ORCID: https://orcid.org/0000-0001-6460-2471)
- Frank Fiebig
- Andreas Rank (ORCID: https://orcid.org/0000-0002-5636-0043)
- Jolana Mertová
- Mathias Hänel (ORCID: https://orcid.org/0000-0002-4767-3275)
- Nael Alakel (ORCID: https://orcid.org/0000-0003-3669-5564)
- Tomáš Szotkowski (ORCID: https://orcid.org/0000-0002-1336-7093)
- Lars R. Fransecky (ORCID: https://orcid.org/0000-0002-3658-0284)
- Jan-Henrik Mikesch
- Christoph Schliemann (ORCID: https://orcid.org/0000-0003-1755-9583)
- Andreas Burchert (ORCID: https://orcid.org/0000-0002-8411-8844)
- Maher Hanoun (ORCID: https://orcid.org/0000-0002-1754-8940)
- Uwe Platzbecker (ORCID: https://orcid.org/0000-0003-1863-3239)
- Stefan W. Krause (ORCID: https://orcid.org/0000-0002-5259-4651)
- Richard Noppeney
- Hubert Serve (ORCID: https://orcid.org/0000-0001-8472-5516)
- Tim Sauer (ORCID: https://orcid.org/0000-0001-5412-324X)
- Martin Kaufmann (ORCID: https://orcid.org/0000-0003-0163-2205)
- G. Ehninger
- Gerhard Held (ORCID: https://orcid.org/0000-0002-2932-3140)
- Kerstin Schäfer‐Eckart
Institutions
- Goethe University Frankfurt (DE)
- Philipps University of Marburg (DE)
- German Cancer Research Center (DE)
- Charles University (CZ)
- Heidelberg University (DE)
- University Hospital Augsburg (DE)
- University Hospital Heidelberg (DE)
- Robert Bosch Hospital (DE)
- Universitätsklinikum Erlangen (DE)
- Westpfalz Klinikum (DE)
- Rems-Murr-Klinikum (DE)
- Institute of Haematology and Blood Transfusion (CZ)
- Nuremberg Hospital (DE)
- University Hospital Brno (CZ)
- University Hospital Münster (DE)
- National Center for Tumor Diseases (DE)
- University Hospital Schleswig-Holstein (DE)
- Universitätsklinikum Aachen (DE)
- University Hospital Leipzig (DE)
- University Hospital Frankfurt (DE)
- Jena University Hospital (DE)
- Gemeinschaftsklinikum Mittelrhein (DE)
- University Hospital Kralovske Vinohrady (CZ)
- University Medical Centre Mannheim (DE)
- Klinikum Chemnitz (DE)
- University of Duisburg-Essen (DE)
- Palacký University Olomouc (CZ)
- Technische Universität Dresden (DE)
- RWTH Aachen University (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1200/jco.24.00235
- Citations
- 14
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 6.36