Inflammatory protein associations with brain MRI measures: Framingham Offspring Cohort
Higher CDCP1, IL6, OPG, and 4E.BP1 levels were associated with smaller TCBV. Higher levels of HGF, IL8 and MMP10 were associated with smaller TCBV, CWV and FWV. Higher levels of SCF and TWEAK, were associated with larger TCBV. Significance diminished in models adjusting for CVD risk factors. Associations were observed exclusively in males.
Authors
- Yuan Fang (ORCID: https://orcid.org/0000-0001-8430-1238)
- Joanne M. Murabito (ORCID: https://orcid.org/0000-0002-0192-7516)
- Margaret F. Doyle (ORCID: https://orcid.org/0000-0001-6769-5386)
- Wei Qiao Qiu (ORCID: https://orcid.org/0000-0002-2082-2410)
- Michael L. Alosco (ORCID: https://orcid.org/0000-0002-8113-8428)
- Jiachen Chen (ORCID: https://orcid.org/0000-0002-1941-2326)
- Kathryn L. Lunetta (ORCID: https://orcid.org/0000-0002-9268-810X)
- Jesse Mez (ORCID: https://orcid.org/0000-0003-1438-5442)
- Ahmed A.Y. Ragab
- Claudia Liliana Satizábal (ORCID: https://orcid.org/0000-0002-1115-4430)
Institutions
- Boston University (US)
- University of Vermont (US)
- Binghamton University (US)
- Boston Medical Center (US)
- The University of Texas at San Antonio Health Science Center (US)
- National Heart, Lung, and Blood Institute (US)
- Institute for Neurodegenerative Disorders (US)
- Framingham Heart Study (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1002/alz.14147
- Citations
- 11
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 5.17
Funders
- National Institute on Aging
- National Heart, Lung, and Blood Institute