Clinical and Genomic Features of Classical and Basal Transcriptional Subtypes in Pancreatic Cancer
The SB subtype is a strong independent predictor of worse outcomes, regardless of the up-front chemotherapy regimen used. Clinical trials should further investigate pancreatic cancer transcriptional subtypes as a prognostic and predictive biomarker.
Authors
- Stephanie K. Dougan (ORCID: https://orcid.org/0000-0002-2263-363X)
- Kimberly J. Perez (ORCID: https://orcid.org/0000-0002-5745-2994)
- Kevin S. Kapner (ORCID: https://orcid.org/0000-0002-2306-2373)
- Rachna T. Shroff (ORCID: https://orcid.org/0000-0003-0066-2672)
- James M. Cleary (ORCID: https://orcid.org/0000-0001-7213-3951)
- Rishi Surana (ORCID: https://orcid.org/0000-0002-8471-9236)
- Hannah L. Williams (ORCID: https://orcid.org/0000-0003-0434-3900)
- Michael J. Pishvaian (ORCID: https://orcid.org/0000-0002-1165-9041)
- Alex Farrell (ORCID: https://orcid.org/0000-0001-5702-3906)
- Srivatsan Raghavan (ORCID: https://orcid.org/0000-0002-5374-9918)
- Sanjay Goel (ORCID: https://orcid.org/0000-0002-2798-7568)
- Harshabad Singh (ORCID: https://orcid.org/0000-0001-6295-2013)
- Brandon M. Huffman (ORCID: https://orcid.org/0000-0002-0768-3145)
- Chen Yuan (ORCID: https://orcid.org/0000-0002-0708-9648)
- Brian M. Wolpin (ORCID: https://orcid.org/0000-0002-0455-1032)
- Matthew James Oberley (ORCID: https://orcid.org/0000-0001-6419-2513)
- Benjamin A. Weinberg (ORCID: https://orcid.org/0000-0002-0408-4817)
- Raja R. Narayan (ORCID: https://orcid.org/0000-0001-7938-4702)
- Jonathan Andrew Nowak (ORCID: https://orcid.org/0000-0002-0943-7407)
- George W. Sledge (ORCID: https://orcid.org/0000-0003-0297-0775)
- Alexander C. Jordan (ORCID: https://orcid.org/0000-0002-3006-7033)
- Andressa Dias Costa (ORCID: https://orcid.org/0000-0003-1046-4899)
- Andrew J. Aguirre (ORCID: https://orcid.org/0000-0002-0701-6203)
- Joanne Xiu (ORCID: https://orcid.org/0000-0001-8744-5827)
- David B. Spetzler (ORCID: https://orcid.org/0000-0002-9531-0970)
Institutions
- Rutgers, The State University of New Jersey (US)
- Broad Institute (US)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- University of Arizona (US)
- Johns Hopkins University (US)
- Georgetown University (US)
- Johns Hopkins Medicine (US)
- Georgetown University Medical Center (US)
- Loma Linda University Health Care (US)
- Sidney Kimmel Cancer Center (US)
- Dana-Farber Cancer Institute (US)
- Dana-Farber/Harvard Cancer Center (US)
- Caris Life Sciences (United States) (US)
- Arizona Oncology (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-1164
- Citations
- 26
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 7.35