Bacteriocin distribution patterns in <i>Enterococcus faecium</i> and <i>Enterococcus lactis</i> : bioinformatic analysis using a tailored genomics framework
This work significantly expands the knowledge on the understudied bacteriocin diversity in opportunistic enterococci, revealing their contribution in the adaptation to different environments. It underscores the importance of placing increased emphasis on genetic platforms carrying bacteriocins as well as on cryptic plasmids that often exclusively harbor bacteriocins since bacteriocin production can significantly contribute to plasmid maintenance, potentially facilitating their stable transmission across generations. Further characterization of strain-level bacteriocin landscapes could inform strategies to combat high-risk clones. Overall, these insights provide a framework for unraveling the therapeutic and biotechnological potential of bacteriocins.
Authors
- Val F. Lanza (ORCID: https://orcid.org/0000-0003-0870-9500)
- Ana R. Freitas (ORCID: https://orcid.org/0000-0002-7326-4133)
- Ana P. Tedim (ORCID: https://orcid.org/0000-0003-1016-7173)
- Teresa M. Coque (ORCID: https://orcid.org/0000-0002-8228-3491)
- Carla Novais (ORCID: https://orcid.org/0000-0002-3826-6731)
- Luı́sa Peixe
- Ana C. Almeida-Santos (ORCID: https://orcid.org/0000-0001-6711-4780)
Institutions
- Universidade do Porto (PT)
- Instituto Cajal (ES)
- Instituto de Salud Carlos III (ES)
- Cooperativa de Ensino Superior Politécnico e Universitário (PT)
- Instituto Ramón y Cajal de Investigación Sanitaria (ES)
- Instituto de Investigación Biomédica de Salamanca (ES)
- Hospital Universitario Río Hortega (ES)
Publication Details
- Journal
- Applied and Environmental Microbiology
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1128/aem.01376-24
- Citations
- 17
- Primary Topic
- Probiotics and Fermented Foods
- Type
- article
- Field-Weighted Citation Impact
- 5.92
Funders
- Ministério da Ciência, Tecnologia e Ensino Superior
- Applied Molecular Biosciences Unit
- Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica
- Fundação para a Ciência e a Tecnologia