PTN from Leydig cells activates SDC2 and modulates human spermatogonial stem cell proliferation and survival via GFRA1
Our results uncover a novel mechanism of human SSC regulation by the testicular microenvironment and suggest a potential therapeutic target for male infertility.
Authors
- Zenghui Huang (ORCID: https://orcid.org/0000-0003-3242-5946)
- Lvjun Liu (ORCID: https://orcid.org/0009-0008-4503-6441)
- Dai Zhou (ORCID: https://orcid.org/0000-0003-4577-8898)
- Huan Zhang (ORCID: https://orcid.org/0009-0009-1420-0154)
- Fang Zhu (ORCID: https://orcid.org/0000-0001-6234-2901)
- Xueheng Zhao (ORCID: https://orcid.org/0009-0001-1050-2579)
Institutions
- Central South University (CN)
- Hunan Normal University (CN)
- Reproductive & Genetic Hospital CITIC-Xiangya (CN)
- National Engineering Research Center of Human Stem Cells (CN)
- Changsha Hospital for Maternal and Child Health Care (CN)
- Hunan Provincial Maternal and Child Health Hospital (CN)
Publication Details
- Journal
- Biological Research
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1186/s40659-024-00546-6
- Citations
- 5
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 2.69
Funders
- Hunan Normal University
- Natural Science Foundation of Hunan Province