The improvement of modified Si-Miao granule on hepatic insulin resistance and glycogen synthesis in type 2 diabetes mellitus involves the inhibition of TNF-α/JNK1/IRS-2 pathway: network pharmacology, molecular docking, and experimental validation
Network pharmacology and molecular docking help us predict potential mechanism of mSMG and further guide experimental validation. mSMG and its representative compound berberine improve hepatic IR and glycogen synthesis, and its mechanism may be related to the inhibition of TNF-α/JNK1/IRS-2 pathway.
Authors
- Zebiao Cao (ORCID: https://orcid.org/0000-0003-4650-803X)
- Xianzhe Wang (ORCID: https://orcid.org/0000-0002-6237-9461)
- Zhili Zeng (ORCID: https://orcid.org/0000-0002-1122-2974)
- Qiyun Lu
- Guanjie Fan (ORCID: https://orcid.org/0000-0002-2711-3481)
- Lu Sun (ORCID: https://orcid.org/0000-0003-2393-241X)
- Yu‐Ping Lin
- Zhaojun Yang
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
- Guangdong Academy of Medical Sciences (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1186/s13020-024-00997-9
- Citations
- 4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- Guangdong Provincial Hospital of Traditional Chinese Medicine
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Guangzhou University of Chinese Medicine
- Traditional Chinese Medicine Bureau of Guangdong Province
- Guangzhou University
- Basic and Applied Basic Research Foundation of Guangdong Province