Design of fully synthetic signal peptide library and its use for enhanced secretory production of recombinant proteins in Corynebacterium glutamicum
By screening a fully synthetic signal peptide library, we achieved improved production of target proteins compared to previous results using well-known signal peptides. Our synthetic library provides a useful resource for the development of an optimal secretion system for various recombinant proteins in C. glutamicum, and we believe this bacterium to be a more promising workhorse for the bioindustry.
Authors
- Ki Jun Jeong (ORCID: https://orcid.org/0000-0002-9432-7519)
- Seong Min Lee
- Eun Jung Jeon (ORCID: https://orcid.org/0000-0002-9314-7997)
- Hee Soo Hong
Institutions
- Korea Advanced Institute of Science and Technology (KR)
- Korea Research Institute of Bioscience and Biotechnology (KR)
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1186/s12934-024-02516-9
- Citations
- 7
- Primary Topic
- Microbial Metabolic Engineering and Bioproduction
- Type
- article
- Field-Weighted Citation Impact
- 1.64
Funders
- National Research Foundation
- Ministry of Agriculture, Food and Rural Affairs
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea
- Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry