Upregulation of Phosphodiesterase 7A Contributes to Concurrent Pain and Depression via Inhibition of cAMP-PKA-CREB-BDNF Signaling and Neuroinflammation in the Hippocampus of Mice
Hippocampal PDE7A mediated concurrent chronic pain and depression in both mouse models by inhibiting cAMP-PKA-CREB-BDNF signaling. Inhibiting PDE7A or activating cAMP-PKA-CREB-BDNF signaling are potential strategies to treat concurrent chronic pain and depression.
Authors
- Yanhan Chen (ORCID: https://orcid.org/0000-0001-9991-8935)
- Shicai Chen (ORCID: https://orcid.org/0000-0002-0135-0040)
- Fang‐fang Zhang (ORCID: https://orcid.org/0000-0002-9348-7596)
- Yan Song (ORCID: https://orcid.org/0000-0002-5847-0254)
- Mingxia Wu
- Han‐Ting Zhang
- Wei Qiang Wang (ORCID: https://orcid.org/0000-0002-1430-1360)
- Feng Zhang (ORCID: https://orcid.org/0000-0001-9401-4339)
- Hao Wang (ORCID: https://orcid.org/0000-0003-1862-8229)
- Zhou Yan-meng
- Haiyang Yu
- Sheng-Hua Zong
Institutions
- Qingdao University (CN)
- Academy of Medical Sciences (GB)
- Taiyuan Maternity and Child Care Hospital (CN)
- Shandong First Medical University (CN)
- Institute of Pharmacology (CZ)
Publication Details
- Journal
- The International Journal of Neuropsychopharmacology
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1093/ijnp/pyae040
- Citations
- 6
- Primary Topic
- Phosphodiesterase function and regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province