Immune checkpoint inhibitor-induced gastrointestinal injury: prevalence of cytomegalovirus, adenovirus and Epstein-Barr virus
While our cohort is small, ICIGI generally demonstrates active inflammation including cryptitis and crypt abscesses in the colon, LCL pattern, and an increase in epithelial apoptosis. Upfront immunohistochemistry for viral infection without high-degree of clinical and histologic suspicion is not recommended.
Authors
- Carissa LaBoy (ORCID: https://orcid.org/0000-0002-0512-3574)
- Maryam Kherad Pezhouh (ORCID: https://orcid.org/0000-0002-0217-5141)
- Jingjing Hu (ORCID: https://orcid.org/0000-0003-1957-2706)
- Yevgen Chornenkyy (ORCID: https://orcid.org/0000-0001-5817-3236)
- Sergei Xavier De Hoyos
Institutions
- Northwestern University (US)
- Beth Israel Deaconess Medical Center (US)
- The Ohio State University Wexner Medical Center (US)
- University of California San Diego (US)
Publication Details
- Journal
- Journal of Clinical Pathology
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1136/jcp-2024-209621
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.85