Anisakis extracellular vesicles elicit immunomodulatory and potentially tumorigenic outcomes on human intestinal organoids
The results here obtained unravel intestinal epithelium response to Anisakis EVs, impacting host's anthelminthic strategies and revealing for the first time to our knowledge the host-parasite interactions in the niche environment of an emerging accidental zoonosis. Use of an innovative EV characterization approach may also be useful for study of other helminth EVs, since the knowledge in this field is very limited.
Authors
- Silvia Rondón (ORCID: https://orcid.org/0000-0003-0928-4110)
- Cecilia Ambrosi (ORCID: https://orcid.org/0000-0003-2163-1613)
- Anna Kashkanova (ORCID: https://orcid.org/0000-0001-7565-017X)
- Stefano D’Amelio (ORCID: https://orcid.org/0000-0002-1871-9553)
- Ilaria Bellini (ORCID: https://orcid.org/0009-0002-2218-7550)
- Vahid Sandoghdar (ORCID: https://orcid.org/0000-0003-2594-4801)
- Anna Teresa Palamara (ORCID: https://orcid.org/0000-0001-8330-4381)
- Daniela Scribano (ORCID: https://orcid.org/0000-0002-2901-265X)
- Agostina Pietrantoni (ORCID: https://orcid.org/0000-0002-1121-4464)
- Serena Cavallero (ORCID: https://orcid.org/0000-0002-2245-9694)
- Annamaria Pronio (ORCID: https://orcid.org/0000-0001-6356-8902)
- Claudia Chiovoloni (ORCID: https://orcid.org/0009-0000-9625-6315)
Institutions
- Vita-Salute San Raffaele University (IT)
- Istituto Superiore di Sanità (IT)
- Policlinico Umberto I (IT)
- Max Planck Institute for the Science of Light (DE)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istituto Pasteur (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1186/s13071-024-06471-7
- Citations
- 8
- Primary Topic
- Parasite Biology and Host Interactions
- Type
- article
- Field-Weighted Citation Impact
- 3.67
Funders
- European Society of Clinical Microbiology and Infectious Diseases
- Sapienza Università di Roma
- Istituto Pasteur-Fondazione Cenci Bolognetti