West African Genetic Ancestry, Neighborhood Deprivation, and Prostate Cancer
This case-control study of men with West African and European ancestry found that West African genetic ancestry was associated with increased odds of prostate cancer among males who resided in neighborhoods with high deprivation but lower odds in more affluent neighborhoods. Thus, neighborhood environments may play a critical role in defining how genetic ancestry modulates prostate cancer risk.
Authors
- Adaora Ezeani
- William Wooten (ORCID: https://orcid.org/0000-0003-1254-7292)
- Margaret S. Pichardo (ORCID: https://orcid.org/0000-0002-9132-4400)
- Amanda M. Acevedo (ORCID: https://orcid.org/0000-0003-3644-1978)
- Bríd M. Ryan (ORCID: https://orcid.org/0000-0003-0038-131X)
- Stefan Ambs (ORCID: https://orcid.org/0000-0001-7651-9309)
- Tsion Z. Minas (ORCID: https://orcid.org/0000-0001-5515-6035)
- Jamirra Franklin
- Wei Tang (ORCID: https://orcid.org/0000-0001-8613-4285)
- Tiffany H. Dorsey (ORCID: https://orcid.org/0009-0003-1334-0098)
- Tanya Agurs‐Collins (ORCID: https://orcid.org/0000-0002-4802-9289)
- Catherine M. Pichardo (ORCID: https://orcid.org/0000-0002-2520-4021)
- Rick A. Kittles (ORCID: https://orcid.org/0000-0002-5004-4437)
- Wayne R. Lawrence (ORCID: https://orcid.org/0000-0002-2992-5897)
- Maeve Bailey‐Whyte (ORCID: https://orcid.org/0000-0002-4539-1223)
- Christopher A. Loffredo (ORCID: https://orcid.org/0000-0002-3134-6894)
- Alexandra R. Harris
- Jia Liu (ORCID: https://orcid.org/0000-0002-9771-192X)
Institutions
- University of Maryland, Baltimore (US)
- National Institutes of Health (US)
- Georgetown University (US)
- University of Limerick (IE)
- Hospital of the University of Pennsylvania (US)
- Georgetown University Medical Center (US)
- National Cancer Institute (US)
- University of Pennsylvania Health System (US)
- AstraZeneca (United States) (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
- University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center
- Morehouse School of Medicine (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1001/jamanetworkopen.2024.33546
- Citations
- 13
- Primary Topic
- Race, Genetics, and Society
- Type
- article
- Field-Weighted Citation Impact
- 7.15
Funders
- U.S. Department of Defense
- National Institutes of Health
- National Cancer Institute