Immunometabolic Signature and Tauopathy Markers in Blood Cells of Progressive Supranuclear Palsy
PSP displays a systemic inflammatory shift of the peripheral immunity, which may justify a metabolic reprogramming of the blood leukocytes. Consistently, the NRF2/HO-1 pathway, a master regulator of inflammatory and metabolic response, was activated. PBMCs also engulf tau proteins, especially p-tau, in a way inverse to the disease severity, allowing for a peripheral tracking of tauopathy in patients. Immunometabolic targets may, therefore, gain relevance to PSP in biomarker or therapeutic purposes. © 2024 International Parkinson and Movement Disorder Society.
Authors
- Massimo Marano (ORCID: https://orcid.org/0000-0001-9885-3666)
- Patrizia Longone (ORCID: https://orcid.org/0000-0001-8964-1637)
- Valentina Nesci (ORCID: https://orcid.org/0009-0003-3702-9608)
- Cristiana Valle (ORCID: https://orcid.org/0000-0002-0914-6511)
- Davide Mascioli (ORCID: https://orcid.org/0009-0009-0292-1640)
- Valerio Chiurchiù (ORCID: https://orcid.org/0000-0002-0316-7311)
- Daniela Maftei (ORCID: https://orcid.org/0000-0002-8679-2840)
- Clara Simonetta (ORCID: https://orcid.org/0009-0007-3269-8684)
- Mariangela Pierantozzi (ORCID: https://orcid.org/0000-0002-4507-4666)
- Alberto Ferri (ORCID: https://orcid.org/0000-0002-4097-0605)
- Henri Zenuni (ORCID: https://orcid.org/0000-0002-1695-1359)
- Tommaso Schirinzi (ORCID: https://orcid.org/0000-0002-2517-6278)
- Jacopo Bissacco (ORCID: https://orcid.org/0009-0003-2350-4121)
- Marco Rosina (ORCID: https://orcid.org/0000-0003-0952-1710)
- Roberta Bovenzi (ORCID: https://orcid.org/0009-0004-4824-0051)
- Alessandro Stefani (ORCID: https://orcid.org/0000-0002-1806-8922)
- Nicola Biagio Mercuri (ORCID: https://orcid.org/0000-0001-6700-7491)
- Federica Veltri
Institutions
- University of Rome Tor Vergata (IT)
- Università Campus Bio-Medico (IT)
- Istituto di Farmacologia Traslazionale (IT)
- Policlinico Tor Vergata (IT)
- Campus Bio Medico University Hospital (IT)
- Fondazione Santa Lucia (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- National Research Council (IT)
Publication Details
- Journal
- Movement Disorders
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1002/mds.30009
- Citations
- 6
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.96
Funders
- European Commission
- Ministero della Salute
- Ministero dell'Università e della Ricerca