Photocatalytic Decarboxylative Allylation of α-Amino Acids and Peptides under Metal-Free Conditions
We developed an organophotoredox catalytic system to facilitate the decarboxylative allylation coupling process concerning α-amino acids and related C-terminal carboxylate peptides using Morita-Baylis-Hillman adducts as allylic precursors. This metal-free method operates under mild conditions and is compatible with various amino acids. The versatility of this protocol, particularly in chemical biology research, has been preliminarily demonstrated through the ligation of bioactive peptide chains.
Authors
- Dongping Wang (ORCID: https://orcid.org/0000-0002-4705-8774)
- Teck‐Peng Loh (ORCID: https://orcid.org/0000-0002-2936-337X)
- Yanyu Lu
- Zhenguo Zhang (ORCID: https://orcid.org/0000-0002-0059-1766)
- Yinlei Zhang
- Shirui Wang (ORCID: https://orcid.org/0000-0002-7554-1587)
- Peizhong Xie (ORCID: https://orcid.org/0000-0002-6777-0443)
- C. Ju
Institutions
- Nanjing Tech University (CN)
- Nanyang Technological University (SG)
- Henan University of Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1021/acs.orglett.4c03038
- Citations
- 7
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- Agency for Science, Technology and Research
- Nanyang Technological University
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province
- Six Talent Peaks Project in Jiangsu Province