P185 CHARACTERISTICS OF CENTRAL HEMODYNAMIC CHANGES IN PREGNANT WOMEN WITH PRE-EXISTING ARTERIAL HYPERTENSION II UZBEK POPULATION DEPENDING BODY MASS INDEX

Background and Objective: In Central Asia, hypertension accounts for 14.5% of all maternal deaths. In Uzbekistan for 2022-2023, pre-existing/chronic hypertension (CHTN) accounts for 3.6% of all maternal deaths. So, the aim was to identify the features of hemodynamic parameters in pregnant women with CHTN Methods: Study included 75 pregnant women of the 2nd-3rd gestation period, divided into 2 groups. Group 1 (n=44) included women without any cardiovascular or somatic pathology (healthy group). Group 2 (n=31) included pregnant women with CHTN (2018 ESC/ESH). HR was assessed, BP was measured, body mass index (BMI) was calculated. Central hemodynamic parameters were assessed using echocardiography. Statistical processing was carried out using Statistica 13.0 program. p < 0.05 was considered statistically significant. Results: Analysis showed, the mean age of 2 gr women was older than in 1 gr, 32.67±4.75 years vs 27.24±5.79(p < 0.0001). The mean level of BP corresponded to mild AH (2018 ESC/ESH), amounting to SBP 153.83±16.43 mmHg in 2 gr vs 102.72±10.42 mmHg in 1 group (p< 0.0001) and to DBP 96.16±7.62 mmHg vs 64.77±5.9 mmHg (p<0.0001). According to BMI 23 women (74.2%) with CHTN were overweight, 15 (48%) were with I and II obesity degree. In healthy group, were only 7 overweight women (16%) and no obese women. Analysis of hemodynamics did not reveal signs of cardiac remodeling (LVH, LVDD), but size of the LV walls, the LV mass were greater in 2 gr. Thus, LVEDD in group 2 was 4.79±0.44 cm versus 4.51±0.42 cm in group 1 (p= 0.0068); IVST was 0.976±0.14 cm versus 0.81±0.07 (p< 0.0001); LVEDV was 108.45 ± 23.72 ml versus 94.25 ± 19.48 (p = 0.0058); LV ind.mass was 90.96 ± 22.94 g/m2 versus 65.11 ± 15.28 g/m2 (p < 0.0001). Moreover, in group 2, E/A ratio was 1.52±0.34 versus 1.28±0.24 in group 1 (p = 0.0012). Conclusion: It was shown that CHTN in pregnancy, in more than 70% of cases, associated with overweight and initial manifestations of cardiac remodeling.