P186 ASSESSMENT OF ECHOCARDIOGRAPHY INDICATORS AND ENDOTHELIAL DYSFUNCTION IN PREGNANT WOMEN WITH GESTATIONAL ARTERIAL HYPERTENSION

Background and Objective: Hypertensive disorders during pregnancy occur in 5–10% of pregnant women worldwide. In Central Asia, hypertension accounts for 14.5% of all maternal deaths. To identify the features of hemodynamic parameters in pregnant women with gestational arterial hypertension (GHTN). Methods: Study included 74 women, who were divided into 2 groups: Group I healthy pregnant women (n=44) and Group II pregnant women with HAG (n=30) according to 2018 ESC/ESH. All pregnant women underwent medical history collection, blood pressure measurement, ECG, B-mode echocardiography, 24-hour blood pressure monitoring, and endothelial function was determined based on an ultrasound cuff test. Statistical analysis of the obtained data was carried out using the STATISTICA 13 program. P <0.05 was considered statistically significant Results: The compared groups were comparable in age (27.24±5.79 years vs. 29.07±6.51 years, P = 0.2085), number of pregnancies (2.55±1.63 vs. 2.5±1.35 P = 0.8901), childbirth (2.11±1.13 vs. 2.13±1.02 P = 0.9378) and gestational age (28.4±3.89 vs. 29.6±4.86 P = 0.2632). The average BP level in II group corresponded to moderately elevated BP, amounting to SBP of 153.17±8.14 mmHg vs 102.72±10.42 mmHg (P<0.0001), according to DBP 96±4.62 mmHg. vs 64.77±5.9 mmHg. in group 1 (P <0.0001). Body mass index was normal in 37 women (84%) with normotension, while all pregnant women (100%) with GAG were overweight (n=14; 46.6%) and obese (n=16; 53.4%) respectively. Analysis of central hemodynamic parameters did not reveal any signs of cardiac remodeling (LVH, LVDD). Echocardiography did not reveal any statistically significant deviations. But in pregnant women with GHTN, signs of endothelial dysfunction were revealed according to the results of the cuff test ^D (%) was 7.93 ± 2.03 versus 10.97 ± 2.73 (P < 0.0001). Conclusion: According to the results of this study, initial manifestations of diastolic dysfunction were identified among pregnant women with GHTN who are overweight.