Translational modelling to predict human pharmacokinetics and pharmacodynamics of a Bruton's tyrosine kinase‐targeted protein degrader BGB‐16673
The presented simplified mechanistic model with reduced number of model parameters is practically easier to be applied to research projects compared with the full mechanistic model. It can be used as a tool to better understand the PK/PD behaviour for targeted protein degraders and increase the confidence when moving to the clinical stage.
Authors
- Ming Jiang
- Wei Jun Jin (ORCID: https://orcid.org/0000-0002-4796-5390)
- Taichang Zhang
- Bernd Meibohm (ORCID: https://orcid.org/0000-0003-3923-3648)
- Yue Wu (ORCID: https://orcid.org/0000-0002-7349-959X)
- Xinfeng Hou
- Bo Zhang (ORCID: https://orcid.org/0009-0005-2899-0434)
- Ye Liu (ORCID: https://orcid.org/0000-0003-1716-7037)
- Fan Wang (ORCID: https://orcid.org/0000-0001-9806-5037)
- Wenjing Zhang (ORCID: https://orcid.org/0000-0002-6076-8017)
- Haitao Wang (ORCID: https://orcid.org/0000-0001-6910-974X)
- Xiaona Sun
Institutions
- University of Tennessee Health Science Center (US)
- BeiGene (China) (CN)
- Regend Therapeutics (China) (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1111/bph.17332
- Citations
- 6
- Primary Topic
- Protein Degradation and Inhibitors
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- BeiGene