ZDHHC20 Activates AKT Signaling Pathway to Promote Cell Proliferation in Hepatocellular Carcinoma
High expression of ZDHHC20 promotes the proliferation and tumor growth of HCC by activating the PI3K-AKT signaling pathway. The PI3K inhibitor LY294002 and the AKT inhibitor MK2206 inhibit the promotional effects of ZDHHC20 on the proliferation of HCC and the growth of tumors.
Authors
- Xiaoju Huang
- Pian Liu (ORCID: https://orcid.org/0000-0001-5780-3902)
- Junpeng Meng
- Dan Zhang (ORCID: https://orcid.org/0000-0002-7363-4157)
- Mengmeng Wang (ORCID: https://orcid.org/0009-0009-7289-3219)
Institutions
- Union Hospital (HK)
- Shanxi Medical University (CN)
- Wuhan Union Hospital (CN)
- Second Hospital of Shanxi Medical University (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Hepatocellular Carcinoma
- Published
- 2024-09-01
- DOI
- https://doi.org/10.2147/jhc.s457682
- Citations
- 8
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.35
Funders
- National Natural Science Foundation of China