Local TSH/TSHR signaling promotes CD8 <sup>+</sup> T cell exhaustion and immune evasion in colorectal carcinoma
The present findings highlighted the role of endogenous TSH/TSHR signaling in CD8<sup>+</sup> T cell exhaustion and immune evasion in CRC. TSHR may be suitable as a predictive and therapeutic biomarker in CRC immunotherapy.
Authors
- Rong Shen (ORCID: https://orcid.org/0000-0002-7155-1876)
- Ceng Zhang (ORCID: https://orcid.org/0000-0002-1335-6618)
- Jianbiao Xiao
- Zhizhang Wang (ORCID: https://orcid.org/0000-0002-4699-953X)
- Mingzhou Li (ORCID: https://orcid.org/0000-0001-8681-7684)
- Huiling Hu (ORCID: https://orcid.org/0000-0001-6984-9377)
- Qin Zhu (ORCID: https://orcid.org/0000-0002-9864-5434)
- Wanqi Zhan
- Zhaowen Zhang
- Guanglong Liu (ORCID: https://orcid.org/0000-0002-2357-1928)
- Sisi Zeng
- Shaowan Xu
- Liang Li (ORCID: https://orcid.org/0000-0003-2424-4926)
- Feifei Wang (ORCID: https://orcid.org/0000-0002-5962-3136)
- Yanan Wang (ORCID: https://orcid.org/0000-0002-0327-0458)
- Zhiyang Li (ORCID: https://orcid.org/0000-0002-5481-3985)
- Yunshi Liang (ORCID: https://orcid.org/0000-0002-0703-1948)
- Qi Hu (ORCID: https://orcid.org/0009-0005-7988-2804)
- Bohan Xu (ORCID: https://orcid.org/0009-0003-7703-4890)
- Zuokang Mao
- Bingsong Li
- Yandong Zhang
Institutions
- Key Laboratory of Guangdong Province (CN)
- Nanfang Hospital (CN)
- Guangzhou First People's Hospital (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cancer Communications
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1002/cac2.12605
- Citations
- 22
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 6.22
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- National Key Research and Development Program of China