Activation of β3-adrenergic receptor by mirabegron prevents aortic dissection/aneurysm by promoting lymphangiogenesis in perivascular adipose tissue
Our findings illustrated the therapeutic potential of β3-AR activation by mirabegron on AD/AA, which promoted lymphangiogenesis by increasing adipocyte-derived VEGF-C and, therefore, ameliorated PVAT inflammation.
Authors
- Ze-Bei Zhang
- Xin Pan (ORCID: https://orcid.org/0009-0007-6076-2882)
- Jiaqi Li (ORCID: https://orcid.org/0009-0006-3489-1608)
- Xiaohong Chen (ORCID: https://orcid.org/0000-0002-9797-8384)
- Jing-Rong Lin (ORCID: https://orcid.org/0000-0001-6397-4716)
- Aijun Sun (ORCID: https://orcid.org/0000-0003-0109-6967)
- Min Zhu (ORCID: https://orcid.org/0000-0002-4891-1781)
- Yu‐Wen Cheng (ORCID: https://orcid.org/0000-0002-5031-7108)
- Lian Xu (ORCID: https://orcid.org/0000-0002-6319-4661)
- Ping-Jin Gao
Institutions
- Tongji University (CN)
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Ruijin Hospital (CN)
- Zhongshan Hospital (CN)
- Shanghai Institute of Hypertension (CN)
- Shanghai Tenth People's Hospital (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1093/cvr/cvae213
- Citations
- 18
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 7.24