<scp>CAF</scp>‐secreted <scp>COL5A2</scp> activates the <scp>PI3K</scp>/<scp>AKT</scp> pathway to mediate erlotinib resistance in head and neck squamous cell carcinoma
Erlotinib resistance in HNSCC is significantly influenced by the tumor microenvironment (TME), particularly through CAFs and the PI3K/AKT pathway. Targeting these mechanisms may offer new therapeutic strategies to overcome resistance in HNSCC patients.
Authors
- Wenkai Zhou (ORCID: https://orcid.org/0000-0002-4622-2384)
- Tong Ji (ORCID: https://orcid.org/0000-0002-5119-0305)
- Jie Yang (ORCID: https://orcid.org/0000-0003-0076-6666)
- Yibo Guo
- Zheqi Liu (ORCID: https://orcid.org/0000-0003-1587-9698)
- Yang Wang (ORCID: https://orcid.org/0000-0002-0611-3669)
- Yu‐Qing Zhang (ORCID: https://orcid.org/0000-0001-7670-386X)
- Mingtao Chen (ORCID: https://orcid.org/0000-0001-7316-387X)
- Guanying Feng (ORCID: https://orcid.org/0000-0002-7959-4846)
Institutions
- Sun Yat-sen University (CN)
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Xian Central Hospital (CN)
- Shanghai Stomatological Hospital (CN)
- Shanghai Ninth People's Hospital (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Shanghai Clinical Research Center (CN)
Publication Details
- Journal
- Oral Diseases
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1111/odi.15130
- Citations
- 4
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Shanghai Anti-Cancer Association
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation