The age-dependent development of abnormal cardiac metabolism in the peroxisome proliferator-activated receptor α-knockout mouse
Aged PPARα-KO mice demonstrated higher cardiac PDH flux compared to controls, facilitated by increased myocardial GLUT4 protein levels, leading to enhanced glucose uptake and glycolysis.
Authors
- Kieran Clarke
- Damian J. Tyler (ORCID: https://orcid.org/0000-0002-0780-8905)
- Vicky Ball (ORCID: https://orcid.org/0000-0002-6441-0303)
- Carolyn A. Carr (ORCID: https://orcid.org/0000-0003-0102-5261)
- Michael S. Dodd (ORCID: https://orcid.org/0000-0002-1217-4660)
- Lucy Ambrose
Institutions
- Oxford Centre for Diabetes, Endocrinology and Metabolism (GB)
- Coventry University (GB)
Publication Details
- Journal
- Atherosclerosis
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1016/j.atherosclerosis.2024.118599
- Citations
- 3
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- British Heart Foundation