Reference‐free thio‐succinimide isomerization characterization by electron‐activated dissociation
This study is a first-to-date identification of thio-succinimide hydrolysis isomers without using synthesized reference materials. This approach should be applicable to all thio-succinimide-linked molecules. Correct identification of thio-succinimide hydrolysis isomers may eventually benefit the development of ADCs in the future.
Authors
- Junyan Yang (ORCID: https://orcid.org/0000-0001-5682-797X)
- Anton I. Rosenbaum (ORCID: https://orcid.org/0000-0003-1939-951X)
- Yue Huang (ORCID: https://orcid.org/0000-0003-2788-0856)
- Jiaqi Yuan (ORCID: https://orcid.org/0000-0003-4575-452X)
Institutions
- AstraZeneca (United States) (US)
Publication Details
- Journal
- Rapid Communications in Mass Spectrometry
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1002/rcm.9910
- Citations
- 4
- Primary Topic
- Mass Spectrometry Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.96
Funders
- AstraZeneca