Optimizing a Facile and Rapid Method for Extraction of Flavonoids from <i>Matricaria Chamomilla</i> Using TiO ₂ Nanoparticles

Abstract Flavonoids are known as valuable natural compounds and Chamomile is a rich source of flavonoids. The extraction efficiency of flavonoids is affected by various conditions. So it appears necessary to develop a practical method for the extraction of these compounds. In this study, we attempted to extract the phenolic compounds from chamomile using the surface capacity of titanium oxide nanoparticles (TiO 2 ). UV and FT‐IR spectroscopy was used to determine the accuracy of the binding. The HPLC‐PDA technique was used for the quantification of phenolic compounds and the recovery test result was 84 %. Determining the antioxidant, phenolic, and flavonoid contents suggested that the developed method is successful for the extraction of phenolic compounds. The influential extraction parameters after optimization consisted of the pH of 7, extraction temperature of 25 °C, extraction time of 15 min, and TiO 2 nanoparticle concentration of 4 mM. The method seems acceptable for industrial applications.