Plasma haem oxygenase-1 may represent a first-in-class biomarker of oxidative stress in rheumatoid arthritis
In eRA, plasma levels of HO-1 were increased and correlated with disease and radiographic progression. A baseline measurement of plasma HO-1 levels demonstrated superior performance to currently used clinical and serological disease markers in the prediction of radiographic progression. Plasma HO-1 may function as a first-in-class biomarker of synovial oxidative stress in RA.
Authors
- Bent Deleuran (ORCID: https://orcid.org/0000-0002-7079-1587)
- Morten Aagaard Nielsen (ORCID: https://orcid.org/0000-0003-1077-9727)
- Peter Junker (ORCID: https://orcid.org/0000-0002-2684-9964)
- Lykke Midtbøll Ørnbjerg (ORCID: https://orcid.org/0000-0002-7832-6831)
- Malene Hvid (ORCID: https://orcid.org/0000-0002-3602-4261)
- B Andersen
- Kim Hørslev‐Petersen (ORCID: https://orcid.org/0000-0002-5475-7610)
- Merete Lund Hetland (ORCID: https://orcid.org/0000-0003-4229-6818)
- Mikkel Østergaard (ORCID: https://orcid.org/0000-0003-3690-467X)
- Stinne Ravn Greisen (ORCID: https://orcid.org/0000-0003-2922-3307)
- Kristian Stengaard‐Pedersen (ORCID: https://orcid.org/0000-0003-0779-8054)
Institutions
- University of Copenhagen (DK)
- University of Southern Denmark (DK)
- Aarhus University (DK)
- Odense University Hospital (DK)
- Aarhus University Hospital (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Regional Hospital Horsens (DK)
Publication Details
- Journal
- Scandinavian Journal of Rheumatology
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1080/03009742.2024.2392364
- Citations
- 3
- Primary Topic
- Heme Oxygenase-1 and Carbon Monoxide
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Gigtforeningen
- Aarhus Universitets Forskningsfond