The Analysis Study of Evaluating The Efficacy and Safety of Percutaneus Coronary Intervention (PCI) versus EDTA (chelation therapy) for Coronary Artery Disease : A Comprehensive Systematic Review

Background: Percutaneous coronary intervention (PCI) is a pivotal treatment for patients with stable coronary artery disease (CAD), yet its overall effectiveness remains limited. This systematic review seeks to compare the outcomes of these interventions and offer guidance for clinical decision-making. Methods: Adhering to PRISMA 2020 guidelines, this review focused on full-text articles published in English from 2012 to 2024. Result: The review analyzed over 800 publications from these databases. After an initial screening process, eight studies were selected for detailed examination. These selected studies underwent a rigorous review to ensure comprehensive and precise evaluation. Conclusion: While both EDTA and PCI represent advanced treatment options for CAD, their effectiveness is contested due to their complexity and high costs. The systematic review indicates that PCI may offer greater benefits for patients with chronic total occlusions (CTO), showing lower mortality and myocardial infarction (MI) rates.