In vivo measurements of change in tissue oxygen level during irradiation reveal novel dose rate dependence
While UHDR irradiation induces measurable oxygen depletion in tissues, the observed changes in oxygenation levels do not support the hypothesis that ROD-induced radioresistance is responsible for the FLASH tissue-sparing effect at clinically relevant doses and dose rates. These findings highlight the need for further investigation into alternative mechanisms underlying the FLASH effect.
Authors
- Paola Ballesteros‐Zebadúa (ORCID: https://orcid.org/0000-0003-1263-2163)
- Marie‐Catherine Vozenin (ORCID: https://orcid.org/0000-0002-2109-8073)
- Mirna El Khatib (ORCID: https://orcid.org/0000-0002-1524-3764)
- Benoît Petit (ORCID: https://orcid.org/0009-0003-9397-4583)
- Javier Franco‐Pérez (ORCID: https://orcid.org/0000-0001-9670-8502)
- Veljko Grilj (ORCID: https://orcid.org/0000-0001-6573-8063)
- Ron Leavitt
- Ryan Paisley
Institutions
- University Hospital of Geneva (CH)
- University of Pennsylvania (US)
- University of Lausanne (CH)
Publication Details
- Journal
- Radiotherapy and Oncology
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1016/j.radonc.2024.110539
- Citations
- 23
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 9.64
Funders
- National Science Foundation
- Foundation for the National Institutes of Health
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- National Institutes of Health