Modular Access to Aryl Quinolinyl Ketones via Visible‐Light‐Induced Palladium‐Catalyzed Aldehyde C−H Bond Arylation of Quinoline‐8‐Carbaldehydes with Arylboronic Acid
Abstract This article describes the development of a room‐temperature visible‐light‐induced palladium‐catalyzed directed aldehyde C−H bond arylation to access aryl quinolinyl ketones. In this pathway, the Pd catalyst plays a dual role by harvesting light as a photocatalyst and catalyzing the chemical transformation via C−H bond activation. This process is general to synthesize a range of aryl quinolinyl ketones and tolerates many common functional groups. Our methodology was successfully applied to synthesize highly potent tubulin polymerization inhibitors.
Authors
- Mahesh A. Sonawane
- Nileshkumar B. Rathod (ORCID: https://orcid.org/0000-0002-9055-1919)
- Subhash Chandra Ghosh (ORCID: https://orcid.org/0000-0002-6528-1582)
- Dinesh Gopichand Thakur (ORCID: https://orcid.org/0000-0002-3084-1236)
- Sachinkumar D. Patel (ORCID: https://orcid.org/0000-0001-7486-4360)
- Raj N. Patel (ORCID: https://orcid.org/0000-0002-5303-527X)
- Dharmik M. Patel (ORCID: https://orcid.org/0000-0003-2787-8967)
Institutions
- Central Salt and Marine Chemicals Research Institute (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1002/adsc.202400549
- Citations
- 6
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.50
Funders
- Council of Scientific and Industrial Research, India
- Central Salt and Marine Chemicals Research Institute, Council of Scientific and Industrial Research