Multiomics Profiling Distinguishes Sebaceous Carcinoma from Benign Sebaceous Neoplasms and Provides Insight into the Genetic Evolution of Sebaceous Carcinogenesis
The study findings highlight key diagnostic biomarkers for sebaceous carcinoma and suggest that immunotherapy and modulation of cholesterol biosynthesis could be effective treatment strategies.
Authors
- Gabriel J. Starrett (ORCID: https://orcid.org/0000-0001-5871-5306)
- Kerri E. Rieger (ORCID: https://orcid.org/0000-0002-4436-2471)
- Inga Van Buren
- Rama Godse (ORCID: https://orcid.org/0000-0001-9717-3300)
- Eric A. Engels (ORCID: https://orcid.org/0000-0003-0203-6958)
- Benjamin K. Stoff (ORCID: https://orcid.org/0000-0003-4344-9767)
- Isaac Brownell (ORCID: https://orcid.org/0000-0002-0090-9914)
- Kavita Y. Sarin (ORCID: https://orcid.org/0000-0001-5363-3053)
- Michael R. Sargen (ORCID: https://orcid.org/0000-0003-1039-2522)
- Michael C. Royer (ORCID: https://orcid.org/0009-0002-5063-0476)
- Elizabeth Berry (ORCID: https://orcid.org/0000-0002-7574-6718)
- Hans E. Grossniklaus (ORCID: https://orcid.org/0000-0003-0178-9712)
- Kelly J. Yu (ORCID: https://orcid.org/0000-0003-3832-6586)
- Emily Y. Chu (ORCID: https://orcid.org/0000-0001-5625-2782)
- Alisa M. Goldstein (ORCID: https://orcid.org/0000-0002-7538-3582)
- Mary L. Piaskowski (ORCID: https://orcid.org/0000-0001-8453-6416)
- Charles F. Lynch (ORCID: https://orcid.org/0000-0002-9542-6439)
- Suephy C. Chen (ORCID: https://orcid.org/0000-0002-0678-7380)
- Roberto A. Novoa (ORCID: https://orcid.org/0000-0002-7955-0536)
- Brittany C. Baikie (ORCID: https://orcid.org/0000-0002-9844-1589)
Institutions
- University of Iowa (US)
- National Institutes of Health (US)
- Joint Commission (US)
- Emory University (US)
- Oregon Health & Science University (US)
- Duke University (US)
- Hospital of the University of Pennsylvania (US)
- Pennsylvania Hospital (US)
- Dignity Health (US)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (US)
- Stanford Medicine (US)
- National Cancer Institute (US)
- University of Iowa Health Care (US)
- Center for Cancer Research (US)
- Duke University Hospital (US)
- St. Joseph Medical Center (US)
- Department of Health and Human Services (US)
- Stanford University (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-1327
- Citations
- 3
- Primary Topic
- Nonmelanoma Skin Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Institutes of Health
- Joint Pathology Center
- National Cancer Institute
- Division of Cancer Epidemiology and Genetics, National Cancer Institute