Therapeutic potential of <i>Cordyceps sinensis</i> targeting oxidative stress and inflammatory response in the treatment of COPD rats: insights from metabolomics analysis

This study aimed to investigate the effects of wild <i>Cordyceps sinensis</i> on chronic obstructive pulmonary disease (COPD) rats through metabolomics approach, combined with biochemical parameters evaluations. Consequently, <i>C. sinensis</i> exhibited regulatory effects on the lung's metabolic profiles in COPD rats. Treatment with <i>C. sinensis</i> potentially modulated glycerophospholipid metabolism, glutathione metabolism, and tryptophan metabolism, thereby alleviating oxidative stress (by decreasing MDA and GSSG, while increasing SOD and GSH) and inflammatory response (by inhibiting TNF-α, IL-8, and MMP-9) in COPD rats while improving lung tissue damage.