Proteomic analysis of two novel peptides from the <i>Odontobuthus doriae</i> scorpion venom
The venom of the <i>Odontobuthus doriae</i> scorpion, prevalent in East Asia and Iran, has not been fully characterized. This study provides the first proteomic profile of <i>O. doriae</i> venom to explore its potential as a medical. 2D-PAGE analysis revealed 96 protein spots with isoelectric points from 3 to 9 and molecular weights between 6.6 to 205 kDa. Fourteen toxin fractions were isolated via HPLC, and SDS-PAGE showed seven protein bands ranging from 3.8 to 182 kDa. MALDI-TOF MS identified Peptide 1 and Peptide 2, resembling Hemoglobin beta-2 chain and Chaperonin HSP60 and suggest potential therapeutic applications for P1 and P2.
Authors
- Jamil Zargan (ORCID: https://orcid.org/0000-0002-0792-1756)
- Ehsan Jahangirian (ORCID: https://orcid.org/0000-0002-9982-7846)
- Haider Ali Khan (ORCID: https://orcid.org/0000-0003-0586-3633)
- Shakir Ali (ORCID: https://orcid.org/0000-0002-4002-1231)
Institutions
- Imam Hossein University (IR)
- Hamdard University (PK)
- Jamia Hamdard (IN)
Publication Details
- Journal
- Journal of Asian Natural Products Research
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1080/10286020.2024.2403612
- Primary Topic
- Venomous Animal Envenomation and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00