Elucidating ferroptosis mechanisms in heart failure through transcriptomics, single-cell sequencing, and experimental validation
This study provides novel insights into the role of ferroptosis in heart failure by identifying and validating DFRGs that exhibit differential expression across various cell types. The differential expression patterns of these genes, particularly SLC39A14 and QSOX1, indicate their potential involvement in the pathophysiological mechanisms contributing to HF. These findings offer new insights for the development of targeted therapies for HF.
Authors
- Lingyu Han (ORCID: https://orcid.org/0009-0007-0595-5438)
- Kaiyuan Li (ORCID: https://orcid.org/0000-0001-5037-632X)
- Jun Ye (ORCID: https://orcid.org/0000-0002-7958-877X)
- Zhipeng Zheng
- Li Zhu
- Min Sha
- Jing Tian
- Peng Liu (ORCID: https://orcid.org/0000-0001-9948-0259)
Institutions
- Nanchang University (CN)
- Dalian Medical University (CN)
- Nantong University (CN)
- Jinan Central Hospital (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- The Affiliated Taizhou People's Hospital of Nanjing Medical University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Cellular Signalling
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1016/j.cellsig.2024.111416
- Citations
- 5
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 2.09