Targeting the PI3K/AKT signaling pathway with PNU120596 protects against LPS-induced acute lung injury
PNU120596 exhibits promising therapeutic potential for the treatment of acute lung injury, potentially by targeting the PI3K/AKT signaling pathway. These findings suggest that modulation of the α7 nicotinic acetylcholine receptor with PNU120596 may offer a viable strategy for the management of ALI, warranting further investigation and potential clinical applications.
Authors
- Feng Liang
- Fengrui Yang (ORCID: https://orcid.org/0000-0002-8558-1419)
- Zixin Hou
- Qiang Zhang (ORCID: https://orcid.org/0000-0003-0819-7031)
- Yuxia Wang
- Junwen Liu
Institutions
- Huaihua University (CN)
- Hunan University (CN)
- First Affiliated Hospital of University of South China (CN)
- Hengyang Academy of Agricultural Sciences (CN)
- University of South China (CN)
Publication Details
- Journal
- Journal of Pharmacy and Pharmacology
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1093/jpp/rgae076
- Citations
- 6
- Primary Topic
- Nicotinic Acetylcholine Receptors Study
- Type
- article
- Field-Weighted Citation Impact
- 1.40