TGF-β1 and FOXM1 siRNA co-loaded nanoparticles by disulfide crosslinked PEG-PDMAEMA for the treatment of triple-negative breast cancer and its bone metastases in vitro
PDMAEMA-SS-PEG-SS-PDMAEMA was suitable for TGF-β1 siRNA and FOXM1 siRNA delivery, exhibiting a synergetic inhibition effect on TNBC and its bone metastases, which might be related to its synergetic inhibition on EMT.
Authors
- Wen‐Xiu Xu
- Yanling Gong (ORCID: https://orcid.org/0000-0002-2394-8772)
- Xingbo Wang (ORCID: https://orcid.org/0000-0002-4442-4425)
- Li Pengbiao
- Xu Wan
- Hong Huang
- Songbo Shi
Institutions
- Qingdao University of Science and Technology (CN)
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Gansu Provincial Hospital (CN)
Publication Details
- Journal
- Drug Development and Industrial Pharmacy
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1080/03639045.2024.2404979
- Citations
- 4
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 1.13