Interleukin(IL)-37 attenuates isoproterenol (ISO)-induced cardiac hypertrophy by suppressing JAK2/STAT3-signaling associated inflammation and oxidative stress
ISO-induced cardiac hypertrophy is lessened by IL-37 through the reduction of oxidative stress and inflammation. Additionally, the effects of IL-37 are closely related to inactivation of the JAK2/STAT3 signaling pathway. It is anticipated that IL-37 will one day be used to treat cardiovascular illnesses such as heart hypertrophy.
Authors
- Bingyan Guo (ORCID: https://orcid.org/0000-0002-6625-229X)
- Xiaohua Guo (ORCID: https://orcid.org/0000-0001-8888-4493)
- Donglei Zhang (ORCID: https://orcid.org/0000-0003-1581-0439)
- Pengfei Wang (ORCID: https://orcid.org/0000-0003-1066-0953)
- Jie Yan (ORCID: https://orcid.org/0000-0003-2054-6986)
- Yuxing Qian
- Huiqing Wei
Institutions
- Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1016/j.intimp.2024.113134
- Citations
- 8
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 3.22