Artemisinin attenuates perinatal inflammation and consequent oxidative stress in oligodendrocyte precursor cells by inhibiting IRAK-4 and IRAK-1
Our findings suggest that ART can significantly reduce OPC perinatal inflammation and consequent oxidative stress. The targeted inhibition of IRAK-4 and IRAK-1 by ART may be a potential therapeutic strategy for alleviating abnormalities in white matter development in premature newborns.
Authors
- Feng Zhang (ORCID: https://orcid.org/0000-0002-7845-7970)
- Yue Zhou (ORCID: https://orcid.org/0000-0003-0246-3140)
- Na Gao (ORCID: https://orcid.org/0000-0002-1831-8354)
- Zhixian Gou
- Liqun Lu (ORCID: https://orcid.org/0000-0001-5665-7157)
- Yishi Li (ORCID: https://orcid.org/0000-0003-1694-7242)
- Jingyi Liu (ORCID: https://orcid.org/0000-0001-7360-0267)
- Shiyi Ma
- Mengya Sun (ORCID: https://orcid.org/0000-0003-4906-8092)
- Junfang Sun
- Hong Jiang
- Chunchi Lai
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
- First Affiliated Hospital of Chengdu Medical College (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1016/j.intimp.2024.113117
- Citations
- 4
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.96
Funders
- Chengdu Medical College
- Natural Science Foundation of Shandong Province