Improvement of MASLD and MASH by suppression of hepatic N-acetyltransferase 10
Our findings indicate that NAT10 could regulate lipid metabolism in MASLD and MASH by stabilizing Srebp-1c mRNA and upregulating lipogenic enzymes. This study highlights the role of NAT10 and RNA acetylation in the pathogenesis of MASLD and MASH. Thus, our findings suggest a promising new therapeutic approach, such as the use of NAT10 inhibitor, for treating metabolic liver disease.
Authors
- Yan Lü (ORCID: https://orcid.org/0000-0003-3468-2241)
- Cheng‐Chao Ruan (ORCID: https://orcid.org/0000-0001-5229-9428)
- Yanying Yang (ORCID: https://orcid.org/0000-0002-6695-2069)
- Ming‐Hua Zheng (ORCID: https://orcid.org/0000-0003-4984-2631)
- Yunchen Luo (ORCID: https://orcid.org/0000-0002-9621-1720)
- Cheng Hu (ORCID: https://orcid.org/0000-0003-4314-2386)
- Mingyue Ma (ORCID: https://orcid.org/0000-0002-2394-1300)
- Xinjian Wan (ORCID: https://orcid.org/0000-0002-4201-633X)
- Jie Lu (ORCID: https://orcid.org/0000-0002-4890-555X)
- Ni Zhang (ORCID: https://orcid.org/0000-0002-3570-5452)
- Yuejun Liu (ORCID: https://orcid.org/0000-0002-2711-4847)
- Xiaojing Ma
- Zhixia Dong
- Bing Zhou
- Shuo Zhang (ORCID: https://orcid.org/0009-0008-9045-6293)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Tongren Hospital (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Shanghai Sixth People's Hospital (CN)
- Shanghai Institute of Hematology (CN)
- State Key Laboratory of Medical Neurobiology
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1016/j.molmet.2024.102030
- Citations
- 12
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.64
Funders
- China Association for Science and Technology
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation