Impact of monocarbonyl analogs of curcumin (MACs) C66 and B2BrBC on the expression of diabetes-associated genes in streptozotocin-treated rat pancreatic RIN-m cells—Quantitative RT-PCR array data
This paper presents a dataset obtained from an RT<sup>2</sup>-qPCR array analysis of rat pancreatic RIN-m cells treated with two monocarbonyl analogs of curcumin (MACs), C66 and B2BrBC in the presence or absence of streptozotocin (STZ). The array quantified the expression of 84 genes associated with the onset, development, and progression of diabetes. This dataset provides information on the gene expression profiles of pancreatic cells modulated by two specific MACs in a diabetic context. The data can serve as a foundation for developing new hypotheses, designing follow-up experiments, and identifying novel targets for treatment. It can be used to investigate further the molecular mechanisms underlying the therapeutic effects of these MACs and in comparative studies using other experimental antidiabetic compounds.
Authors
- Jane Bogdanov (ORCID: https://orcid.org/0000-0003-1187-366X)
- Radoslav Stojchevski (ORCID: https://orcid.org/0000-0002-5942-1622)
- Mitko Mladenov (ORCID: https://orcid.org/0000-0003-3475-2131)
- Sara Velichkovikj
- Leonid Poretsky (ORCID: https://orcid.org/0000-0001-7479-9474)
- Nikola Hadzi‐Petrushev (ORCID: https://orcid.org/0000-0002-4498-7359)
- Dimiter Avtanski (ORCID: https://orcid.org/0000-0002-4479-6448)
Institutions
- Northwell Health (US)
- Feinstein Institute for Medical Research (US)
- Lenox Hill Hospital (US)
- Donald & Barbara Zucker School of Medicine at Hofstra/Northwell (US)
- Ss. Cyril and Methodius University in Skopje (MK)
Publication Details
- Journal
- Data in Brief
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1016/j.dib.2024.110952
- Citations
- 1
- Primary Topic
- Curcumin's Biomedical Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.17
Funders
- Fondation pour la Recherche Médicale