Real-world experience with long-term albumin in patients with cirrhosis and ascites
The ANSWER randomised-controlled trial has shown that long-term albumin treatment (LTA) is an effective approach for the management of patients with cirrhosis and ascites. This observational study provides novel information on target patients, modalities and length of treatment, predictors of ascites resolution, stopping criteria, and clinical trajectories of patients on treatment. LTA is a feasible option in the daily clinical practice for the management of ascites when given on top of diuretics. Rather than an alternative therapy, LTA should be integrated with the other treatment options already available for patients with difficult-to-treat ascites. The predictive factors of response identified in the present study can help physicians to individualise LTA and optimise the decision-making process.
Authors
- Paolo Caraceni (ORCID: https://orcid.org/0000-0002-1439-056X)
- Salvatore Piano (ORCID: https://orcid.org/0000-0002-9356-5830)
- Paolo Angeli (ORCID: https://orcid.org/0000-0002-1913-0716)
- Maurizio Baldassarre (ORCID: https://orcid.org/0000-0001-7865-394X)
- Stefania Gioia (ORCID: https://orcid.org/0000-0002-3940-4390)
- Vincenza Calvaruso (ORCID: https://orcid.org/0000-0002-0287-1059)
- Marta Tonon (ORCID: https://orcid.org/0000-0001-8913-0992)
- Marco Domenicali (ORCID: https://orcid.org/0000-0002-5065-7073)
- Giulia Iannone (ORCID: https://orcid.org/0000-0002-3424-1289)
- Roberta Gagliardi (ORCID: https://orcid.org/0000-0002-4275-2783)
- Clara De Venuto
- Giorgio Bedogni (ORCID: https://orcid.org/0000-0002-1495-9306)
- Giacomo Zaccherini (ORCID: https://orcid.org/0000-0002-3219-6963)
- V. Di Marco (ORCID: https://orcid.org/0000-0001-6397-4206)
- Antonio Lombardo (ORCID: https://orcid.org/0000-0003-3088-6458)
- Pierluigi Toniutto (ORCID: https://orcid.org/0000-0002-2566-3041)
- Enrico Pompili (ORCID: https://orcid.org/0000-0003-2467-7027)
- Silvia Nardelli (ORCID: https://orcid.org/0000-0002-7038-9539)
- Greta Tedesco (ORCID: https://orcid.org/0000-0002-4052-7849)
- Davide Bitetto
Institutions
- University of Udine (IT)
- University of Padua (IT)
- Ospedale "Santa Maria delle Croci" di Ravenna (IT)
- Azienda USL di Bologna (IT)
- PromoFirenze (IT)
- Sapienza University of Rome (IT)
- University of Bologna (IT)
Publication Details
- Journal
- JHEP Reports
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1016/j.jhepr.2024.101221
- Citations
- 10
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 3.69