Antibiotic Prophylaxis During Allogeneic Stem Cell transplantation—A Comprehensive Single Center Retrospective Analysis
Our study supports previous reports of noninferiority of allo-HSCT without use of antibiotic prophylaxis with close monitoring and rapid intervention, if infection is suspected. The trend towards improved outcomes without antibiotic prophylaxis, however, might not only be due to the absence of antibiotic prophylaxis but also due to additional progresses in the field over the recent years. While the present study is too small to draw definite conclusions, these results strongly warrant further multicenter studies addressing the potential benefit of omitting antibiotic prophylaxis during allo-HSCT.
Authors
- Peter Brossart (ORCID: https://orcid.org/0009-0002-9324-5527)
- Susanne Rehnelt
- Charlotte Neuerburg
- Tobias A.W. Holderried (ORCID: https://orcid.org/0000-0002-2474-523X)
- Dominik Georg Friedrich Wolf (ORCID: https://orcid.org/0000-0002-4761-075X)
- Marie‐Therese Schmitz (ORCID: https://orcid.org/0000-0003-1351-9381)
- Martin M. Schumacher (ORCID: https://orcid.org/0000-0001-9538-8682)
- Matthias Schmid
- Friederike Schmitz (ORCID: https://orcid.org/0000-0002-5271-1088)
- Marjio Parčina
Institutions
- University Hospital Bonn (DE)
- Düsseldorf University Hospital (DE)
- Integrated Oncology (United States) (US)
- Zimmer Biomet (Germany) (DE)
- Tyrolean Cancer Research Institute (AT)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- Transplantation and Cellular Therapy
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1016/j.jtct.2024.09.011
- Citations
- 8
- Primary Topic
- Neutropenia and Cancer Infections
- Type
- article
- Field-Weighted Citation Impact
- 2.26
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Rheinische Friedrich-Wilhelms-Universität Bonn