Caspase-4 Has Potential Utility as a Colorectal Tissue Biomarker for Dysplasia and Early-Stage Cancer
This study demonstrates that epithelial caspase-4 is selectively expressed in colon tissue during the development of dysplasia. As such, epithelial caspase-4 represents a promising novel tissue biomarker for CRC risk and diagnosis.
Authors
- Elizabeth J. Ryan (ORCID: https://orcid.org/0000-0002-5137-1253)
- Cara Dunne (ORCID: https://orcid.org/0000-0001-6996-7912)
- Joan Manils (ORCID: https://orcid.org/0000-0001-8429-1295)
- Laura Kane (ORCID: https://orcid.org/0000-0002-9107-6240)
- Jacintha O’Sullivan
- Glen A. Doherty (ORCID: https://orcid.org/0000-0003-4384-5049)
- Emma M. Creagh (ORCID: https://orcid.org/0000-0001-7631-4370)
- Brian Flood
- Aoife P. Smith (ORCID: https://orcid.org/0000-0002-7255-3339)
- Stephen McQuaid (ORCID: https://orcid.org/0000-0003-0794-8569)
- Maurice B. Loughrey (ORCID: https://orcid.org/0000-0001-8424-1765)
- Miriam Tosetto
- Joanna Fay (ORCID: https://orcid.org/0000-0001-6294-2886)
- Kieran Sheahan (ORCID: https://orcid.org/0000-0002-5636-6920)
- Donna E McSkeane
- Fatema Alalawi
- Elaine W. Kay
Institutions
- University College Dublin (IE)
- Queen's University Belfast (GB)
- Belfast Health and Social Care Trust (GB)
- University of Ulster (GB)
- Royal College of Surgeons in Ireland (IE)
- Trinity College (CA)
- Trinity College Dublin (IE)
- University of Limerick (IE)
- Beaumont Hospital (IE)
- Ajuntament de L’Hospitalet (ES)
- St. Vincent's University Hospital (IE)
- Royal Victoria Hospital (GB)
- Technological University Dublin (IE)
- St. James's Hospital (IE)
Publication Details
- Journal
- Gastro Hep Advances
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1016/j.gastha.2024.09.007
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Enterprise Ireland
- European Regional Development Fund