Biomarker relationships with small bowel histopathology among malnourished children with environmental enteric dysfunction in a multicountry cohort study
Four commonly used markers of enteric dysfunction were associated with specific histologic features. One-hour urine collection may be insufficient to reflect small bowel permeability in LR testing. While acknowledging the challenges with obtaining relevant tissue, these findings form the basis for further EED biomarker validation research.
Authors
- Subhasish Das (ORCID: https://orcid.org/0000-0002-7852-6569)
- David Coomes (ORCID: https://orcid.org/0000-0003-1815-1969)
- Monica Mweetwa (ORCID: https://orcid.org/0000-0003-2679-3697)
- Paul Kelly (ORCID: https://orcid.org/0000-0003-0844-6448)
- Kanta Chandwe (ORCID: https://orcid.org/0000-0003-1403-8432)
- Nurmohammad Shaikh (ORCID: https://orcid.org/0000-0001-5448-6833)
- Phillip I. Tarr (ORCID: https://orcid.org/0000-0003-4078-7517)
- Mustafa Mahfuz (ORCID: https://orcid.org/0000-0002-4090-785X)
- Asad Ali (ORCID: https://orcid.org/0000-0001-5274-7665)
- Donna M. Denno (ORCID: https://orcid.org/0000-0002-5968-9266)
- Najeeha Talat Iqbal (ORCID: https://orcid.org/0000-0003-4026-5655)
- Kelley VanBuskirk
- Marwa Abdalla
Institutions
- Aga Khan University (PK)
- Queen Mary University of London (GB)
- University of Washington (US)
- Washington University in St. Louis (US)
- International Centre for Diarrhoeal Disease Research (BD)
- University of Zambia (ZM)
- Tropical Gastroenterology & Nutrition group (ZM)
Publication Details
- Journal
- American Journal of Clinical Nutrition
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.ajcnut.2024.02.029
- Citations
- 4
- Primary Topic
- Congenital gastrointestinal and neural anomalies
- Type
- article
- Field-Weighted Citation Impact
- 2.29