Multiplexed immunohistochemical evaluation of small bowel inflammatory and epithelial parameters in environmental enteric dysfunction
Our results support a model of chronic epithelial stress that decreases epithelial differentiation and absorptive function. The close association of several IHC parameters with manual histologic scoring suggests that automated digital quantification of IHC panels complements traditional histomorphologic assessment in EED.
Authors
- Samer Mouksassi (ORCID: https://orcid.org/0000-0002-7152-6654)
- Monica Mweetwa (ORCID: https://orcid.org/0000-0003-2679-3697)
- Paul Kelly (ORCID: https://orcid.org/0000-0003-0844-6448)
- Christopher A. Moskaluk (ORCID: https://orcid.org/0000-0002-7049-681X)
- William A. Petri (ORCID: https://orcid.org/0000-0002-7268-1218)
- Phillip I. Tarr (ORCID: https://orcid.org/0000-0003-4078-7517)
- Mustafa Mahfuz (ORCID: https://orcid.org/0000-0002-4090-785X)
- Zehra Jamil (ORCID: https://orcid.org/0000-0002-2395-4646)
- Asad Ali (ORCID: https://orcid.org/0000-0001-5274-7665)
- Ellen Besa (ORCID: https://orcid.org/0000-0001-5606-9435)
- Shyam S. Raghavan (ORCID: https://orcid.org/0000-0002-3816-1542)
- Donna M. Denno (ORCID: https://orcid.org/0000-0002-5968-9266)
- Tahmeed Ahmed (ORCID: https://orcid.org/0000-0002-4607-7439)
- Sean R. Moore (ORCID: https://orcid.org/0000-0003-1150-6632)
- Kelley VanBuskirk
- Tad Kolterman
- Peter Sullivan
- SM Khodeza Nahar Begum
Institutions
- Aga Khan University (PK)
- Queen Mary University of London (GB)
- University of Washington (US)
- Washington University in St. Louis (US)
- International Centre for Diarrhoeal Disease Research (BD)
- University of Zambia (ZM)
- University of Oxford (GB)
- Tropical Gastroenterology & Nutrition group (ZM)
- Certara (United States) (US)
- Integra LifeSciences (United States) (US)
- University of Virginia (US)
Publication Details
- Journal
- American Journal of Clinical Nutrition
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.ajcnut.2024.02.033
- Citations
- 11
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 6.05