Duodenal transcriptomics demonstrates signatures of tissue inflammation and immune cell infiltration in children with environmental enteric dysfunction across global centers
The transcriptome signatures of EED include specific innate and adaptive immune responses that are consistently elevated across study centers, coupled with reduced detoxification and antioxidant capacities. These data may have implications for targeted interventions to improve EED outcomes.
Authors
- Subhasish Das (ORCID: https://orcid.org/0000-0002-7852-6569)
- David Coomes (ORCID: https://orcid.org/0000-0003-1815-1969)
- Chelsea Marie (ORCID: https://orcid.org/0000-0001-8193-2771)
- Paul Kelly (ORCID: https://orcid.org/0000-0003-0844-6448)
- Lee A. Denson (ORCID: https://orcid.org/0000-0001-8045-7198)
- William A. Petri (ORCID: https://orcid.org/0000-0002-7268-1218)
- Phillip I. Tarr (ORCID: https://orcid.org/0000-0003-4078-7517)
- Mustafa Mahfuz (ORCID: https://orcid.org/0000-0002-4090-785X)
- Asad Ali (ORCID: https://orcid.org/0000-0001-5274-7665)
- Sean R. Moore (ORCID: https://orcid.org/0000-0003-1150-6632)
- Junaid Iqbal (ORCID: https://orcid.org/0000-0002-9426-1193)
- Tahmeed Ahmed
Institutions
- Aga Khan University (PK)
- Cincinnati Children's Hospital Medical Center (US)
- Queen Mary University of London (GB)
- University of Washington (US)
- Washington University in St. Louis (US)
- International Centre for Diarrhoeal Disease Research (BD)
- University of Virginia (US)
Publication Details
- Journal
- American Journal of Clinical Nutrition
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.ajcnut.2024.02.023
- Citations
- 9
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 2.16
Funders
- Bill and Melinda Gates Foundation
- Cincinnati Children's Hospital Medical Center