FOXO1-mTOR pathway in vascular pericyte regulates the formation of type H vessels to control bone metabolism
Our research uncovers a previously unidentified role of FOXO1 in preserving pericyte characteristics and promoting the development of type H vessels. Future translational research targeting the FOXO1-mTOR pathway in pericytes may provide new strategies for the prevention and treatment of age-related osteoporosis in the clinic.
Authors
- Zilong Yao (ORCID: https://orcid.org/0000-0002-1766-3471)
- Hangtian Wu
- Chubin Cheng
- Kaiqun Li (ORCID: https://orcid.org/0000-0003-3322-4345)
- Xianrong Zhang (ORCID: https://orcid.org/0000-0002-0992-5013)
- Mincheng Lu
- Yutian Wang (ORCID: https://orcid.org/0009-0008-8451-600X)
- Bin Yu (ORCID: https://orcid.org/0000-0001-6936-3211)
- Caiyu Cheng
- Mingye Deng
Institutions
- Nanfang Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1016/j.jot.2024.08.010
- Citations
- 3
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.70