Person-level contributions of bipolar polygenic risk score to the prediction of new-onset bipolar disorder in at-risk offspring
The addition of BD-PRS to clinical/demographic predictors in the RC significantly improved its accuracy. BD-PRS predicted BD on the person-level, particularly in offspring of parents with earlier AAO who already had symptoms of anxiety and depression at intake.
Authors
- Benjamin I. Goldstein (ORCID: https://orcid.org/0000-0003-0340-349X)
- Danella Hafeman (ORCID: https://orcid.org/0000-0001-8312-3513)
- Rasim Somer Diler (ORCID: https://orcid.org/0000-0001-5895-6572)
- Boris Birmaher (ORCID: https://orcid.org/0000-0001-9299-6519)
- John Merranko (ORCID: https://orcid.org/0000-0002-0637-0059)
- Dara Sakolsky
- Rudolf Uher (ORCID: https://orcid.org/0000-0002-2998-0546)
- David Axelson (ORCID: https://orcid.org/0000-0002-1348-0707)
- Tina R. Goldstein (ORCID: https://orcid.org/0000-0002-4762-8060)
- Alyson Zwicker (ORCID: https://orcid.org/0000-0003-4500-3128)
- Kelly Monk (ORCID: https://orcid.org/0000-0001-5751-4318)
- Satish Iyengar (ORCID: https://orcid.org/0000-0002-9329-6853)
- Vishwajit L. Nimgaonkar (ORCID: https://orcid.org/0000-0001-8485-5927)
Institutions
- Dalhousie University (CA)
- Nationwide Children's Hospital (US)
- Centre for Addiction and Mental Health (CA)
- University of Pittsburgh (US)
- University of Pittsburgh Medical Center (US)
Publication Details
- Journal
- Journal of Affective Disorders
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1016/j.jad.2024.09.107
- Citations
- 8
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.08
Funders
- American Foundation for Suicide Prevention
- University of Pittsburgh
- Fundación Alicia Koplowitz
- Fondation Brain Canada
- University of Toronto
- Canadian Institutes of Health Research
- National Institute of Mental Health