Safety, pharmacokinetics, biomarker response and efficacy of E6742: a dual antagonist of Toll-like receptors 7 and 8, in a first in patient, randomised, double-blind, phase I/II study in systemic lupus erythematosus

Authors

Yoshiya Tanaka (ORCID: https://orcid.org/0000-0002-0807-7139)
Shizuo Akira (ORCID: https://orcid.org/0000-0001-7602-9617)
Atsushi Kumanogoh (ORCID: https://orcid.org/0000-0003-4749-7117)
Tomonori Ishii (ORCID: https://orcid.org/0000-0001-5361-5824)
Shintaro Yamamuro (ORCID: https://orcid.org/0009-0004-0244-5385)
Fumitoshi Tago (ORCID: https://orcid.org/0000-0002-1235-2244)
Tatsuya Atsumi (ORCID: https://orcid.org/0000-0001-5657-962X)
Mari Aoki (ORCID: https://orcid.org/0009-0007-7145-9125)

Institutions

University of Occupational and Environmental Health Japan (JP)
Hokkaido University (JP)
Tohoku University Hospital (JP)
Tohoku Medical and Pharmaceutical University Hospital (JP)
Hokkaido University Hospital (JP)
Eisai (Japan) (JP)
The University of Osaka (JP)

Publication Details

Journal: RMD Open
Published: 2024-09-01
DOI: https://doi.org/10.1136/rmdopen-2024-004701
Citations: 16
Primary Topic: Systemic Lupus Erythematosus Research
Type: article
Field-Weighted Citation Impact: 7.52

Funders

Japan Agency for Medical Research and Development

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article

Safety, pharmacokinetics, biomarker response and efficacy of E6742: a dual antagonist of Toll-like receptors 7 and 8, in a first in patient, randomised, double-blind, phase I/II study in systemic lupus erythematosus

Yoshiya Tanaka, Shizuo Akira, Atsushi Kumanogoh, Tomonori Ishii et al.

Sep 1, 2024

16 citations

RMD Open

Systemic Lupus Erythematosus Research

7.52

article

Safety, pharmacokinetics, biomarker response and efficacy of E6742: a dual antagonist of Toll-like receptors 7 and 8, in a first in patient, randomised, double-blind, phase I/II study in systemic lupus erythematosus

Yoshiya Tanaka, Shizuo Akira, Atsushi Kumanogoh, Tomonori Ishii, Shintaro Yamamuro, Fumitoshi Tago, Tatsuya Atsumi, Mari Aoki

September 1, 2024article en

16 citations

Abstract

No abstract available for this paper.

RMD OpenVol. 10(3)

University of Occupational and Environmental Health Japan (JP), Hokkaido University (JP), Tohoku University Hospital (JP), Tohoku Medical and Pharmaceutical University Hospital (JP), Hokkaido University Hospital (JP), Eisai (Japan) (JP), The University of Osaka (JP)

Japan Agency for Medical Research and Development

Good health and well-being

Openalex Percentile: Top 2%

Systemic Lupus Erythematosus Research

7.52

DOI Open Access PDF OpenAlex

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