Reduced WNT4 expression in normal skin fibroblasts leads to ‘Dupuytren-like’ changes in the transcriptome
In people susceptible to DD WNT4 is downregulated even in non-fibrotic fibroblasts. Knockdown of WNT4 in normal fibroblasts led to changes that made cells 'DD-like'. This study shows that WNT4 is down regulated in 'non-disease' cells, and that downregulating WNT4 in normal skin fibroblasts leads to widespread 'DD like' changes in the transcriptome, suggesting WNT4 downregulation is a key driver of DD.
Authors
- Andrew Stevenson (ORCID: https://orcid.org/0000-0001-5195-8081)
- Nicole M. Smith (ORCID: https://orcid.org/0000-0002-5519-8152)
- Zhenjun Deng (ORCID: https://orcid.org/0000-0001-9696-2201)
- Mark W. Fear (ORCID: https://orcid.org/0000-0003-3163-4666)
- Nicole Hortin (ORCID: https://orcid.org/0000-0002-0157-1468)
- K. Swaminathan Iyer (ORCID: https://orcid.org/0000-0001-9329-4930)
- Amira Allahham (ORCID: https://orcid.org/0000-0002-6790-7518)
- Lucy Barrett (ORCID: https://orcid.org/0000-0001-9733-9841)
- Fabio Quondamatteo (ORCID: https://orcid.org/0000-0001-6208-3436)
- Nicholas B. Lawler (ORCID: https://orcid.org/0000-0002-8302-5371)
- Aoife O'Brien
- Fiona Wood (ORCID: https://orcid.org/0000-0001-5427-6588)
Institutions
- Royal College of Surgeons in Ireland (IE)
- The University of Western Australia (AU)
- Fiona Stanley Hospital (AU)
- Government of Western Australia Department of Health (AU)
- Fiona Wood Foundation
Publication Details
- Journal
- Heliyon
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e38016
- Citations
- 1
- Primary Topic
- Dupuytren's Contracture and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Children's Hospital Foundation
- Stan Perron Charitable Foundation
- Fiona Wood Foundation