NOX2 mediates NLRP3/ROS facilitating nasal mucosal epithelial inflammation in chronic rhinosinusitis with nasal polyps
This study highlights the crucial role of NOX2 as a key regulator of ROS accumulation and NLRP3 inflammasome activation in CRSwNP, underscoring its potential as a valuable therapeutic target for CRSwNP.
Authors
- Shenghao Cheng (ORCID: https://orcid.org/0000-0001-9497-6319)
- Weihong Jiang (ORCID: https://orcid.org/0000-0001-8369-9694)
- Sihui Wen (ORCID: https://orcid.org/0000-0002-1061-9259)
- Sijie Jiang (ORCID: https://orcid.org/0000-0002-6455-3742)
- Benjian Zhang (ORCID: https://orcid.org/0000-0001-5661-8561)
- Ying‐Chun Shen (ORCID: https://orcid.org/0000-0001-8426-9071)
- Shaobing Xie (ORCID: https://orcid.org/0000-0001-8351-651X)
- Zhihai Xie
Institutions
- University of Hawaiʻi at Mānoa (US)
- Central South University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e38029
- Citations
- 3
- Primary Topic
- Sinusitis and nasal conditions
- Type
- article
- Field-Weighted Citation Impact
- 1.74
Funders
- National Natural Science Foundation of China
- Central South University