Exploring tumor microenvironment in molecular subtyping and prognostic signatures in ovarian cancer and identification of SH2D1A as a key regulator of ovarian cancer carcinogenesis
TME-associated genes were efficient in ovarian cancer molecular subtyping. A TME-based prognosis model was constructed for vigorous prognostic stratification efficacy across multiple datasets. Moreover, we identified a pivotal role of SH2D1A in promoting proliferation and migration in ovarian cancer.
Authors
- Hongrui Guo (ORCID: https://orcid.org/0000-0002-3992-3529)
- Sanyuan Zhang (ORCID: https://orcid.org/0000-0001-8604-874X)
- Jiaolin Yang
- Xiaoli Li
- Jing Lei
- Liwen Zhang
- Xinglin Zhang
- Huancheng Su
Institutions
- Shanxi Medical University (CN)
- First Hospital of Shanxi Medical University (CN)
- Shanxi Provincial Children's Hospital (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e38014
- Citations
- 4
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Health Commission of Shanxi Province
- Shaanxi Health and Family Planning Commission